Liranaftate

Liranaftate

CAS: 88678-31-3

Properties: white to light yellow crystalline powder.

Liranafate was first marketed in Japan in August 2000, and its chemical name is 6-methoxy-2-N-methyl-pyridylamino-thioformic acid-(5, 6, Chemicalbook 7, 8 -Tetrahydro)-2-naphthyl ester is a new type of antifungal drug jointly developed by ZenyakuKogyo Company and Tosoh Corporation

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Liranaftate is a new type of third-generation thiocarbamic acid antifungal drug. It is a third-class chemical drug. It is a squalene epoxidase inhibitor. It inhibits the squalene epoxidation reaction of fungal cell membranes. It hinders the synthesis of ergosterol, which is a constituent of cell membranes, and exerts antifungal effects. The antifungal activity is 8 times that of tolnaftate. The effect of Dermatophytes Chemicalbook is significantly better than clotrimazole. It has strong antifungal effects on skin filamentous fungi (Trichophyton, Microsporum, Epidermophyton), and also shows antifungal effects on other filamentous fungi, dark fungi, and bimorphic fungi. It is suitable for the treatment of tinea capitis, tinea hands, tinea pedis, tinea pedis, onychomycosis, tinea corporis, tinea cruris, tinea versicolor, and candidal vulvovaginitis.

1. Properties: white to light yellow crystalline powder.

2. Melting point (ºC): 98.5~99.5

3. Solubility: Easily soluble in acetone and chloroform, slightly soluble in methanol and ethanol, and almost insoluble in water.

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